New class of molecules may protect brain from stroke, neurodegenerative diseases!

Research has discovered a new class of molecules in the brain that synchronize cell-to-cell communication and neuroinflammation/immune activity in response to injury or diseases. Elovanoids (ELVs) are bioactive chemical messengers made from omega-3 very long chain polyunsaturated fatty acids

Working in neuronal cell cultures from the cerebral cortex and from the hippocampus and a model of ischemic stroke, the researchers found that elovanoids not only protected neuronal cell and promoted their survival, but helped maintain their integrity and stability.

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We know how neurons make synaptic connections with other neurons, however these connections have to be malleable to change strength appropriately. Elovanoids might play a central role as synaptic organizers, especially important in conditions resulting from synaptic dysfunction such as autism or amyotropic lateral sclerosis, for which we have no therapeutic answers.